diff --git a/Marlin/Conditionals.h b/Marlin/Conditionals.h
index 4583a0a5fb..386f836d22 100644
--- a/Marlin/Conditionals.h
+++ b/Marlin/Conditionals.h
@@ -539,6 +539,16 @@
 
   #define ARRAY_BY_EXTRUDERS1(v1) ARRAY_BY_EXTRUDERS(v1, v1, v1, v1)
 
+  /**
+   * With SINGLENOZZLE all "extruders" are in the same place
+   */
+  #if ENABLED(SINGLENOZZLE)
+    #undef EXTRUDER_OFFSET_X
+    #undef EXTRUDER_OFFSET_Y
+    #define EXTRUDER_OFFSET_X { 0 }
+    #define EXTRUDER_OFFSET_Y { 0 }
+  #endif
+
   /**
    * Z_DUAL_ENDSTOPS endstop reassignment
    */
diff --git a/Marlin/Configuration.h b/Marlin/Configuration.h
index 87c72790b3..a79b38e5a9 100644
--- a/Marlin/Configuration.h
+++ b/Marlin/Configuration.h
@@ -120,6 +120,9 @@
 // :[1,2,3,4]
 #define EXTRUDERS 1
 
+// For Cyclops or any "multi-extruder" that shares a single nozzle.
+//#define SINGLENOZZLE
+
 // Offset of the extruders (uncomment if using more than one and relying on firmware to position when changing).
 // The offset has to be X=0, Y=0 for the extruder 0 hotend (default extruder).
 // For the other hotends it is their distance from the extruder 0 hotend.
diff --git a/Marlin/SanityCheck.h b/Marlin/SanityCheck.h
index c499c2c967..3a6e6a895c 100644
--- a/Marlin/SanityCheck.h
+++ b/Marlin/SanityCheck.h
@@ -149,7 +149,9 @@
     #error "EXTRUDERS must be 1 with Z_DUAL_STEPPER_DRIVERS."
   #endif
 
-#endif // EXTRUDERS > 1
+#elif ENABLED(SINGLENOZZLE)
+  #error "SINGLENOZZLE requires 2 or more EXTRUDERS."
+#endif
 
 /**
  * Limited number of servos
diff --git a/Marlin/example_configurations/Felix/Configuration.h b/Marlin/example_configurations/Felix/Configuration.h
index 1092bf3351..3a9a93acd0 100644
--- a/Marlin/example_configurations/Felix/Configuration.h
+++ b/Marlin/example_configurations/Felix/Configuration.h
@@ -120,6 +120,9 @@
 // :[1,2,3,4]
 #define EXTRUDERS 1
 
+// For Cyclops or any "multi-extruder" that shares a single nozzle.
+//#define SINGLENOZZLE
+
 // Offset of the extruders (uncomment if using more than one and relying on firmware to position when changing).
 // The offset has to be X=0, Y=0 for the extruder 0 hotend (default extruder).
 // For the other hotends it is their distance from the extruder 0 hotend.
diff --git a/Marlin/example_configurations/Felix/DUAL/Configuration.h b/Marlin/example_configurations/Felix/DUAL/Configuration.h
index 1c16d5ca0e..4d05e471a5 100644
--- a/Marlin/example_configurations/Felix/DUAL/Configuration.h
+++ b/Marlin/example_configurations/Felix/DUAL/Configuration.h
@@ -120,6 +120,9 @@
 // :[1,2,3,4]
 #define EXTRUDERS 2
 
+// For Cyclops or any "multi-extruder" that shares a single nozzle.
+//#define SINGLENOZZLE
+
 // Offset of the extruders (uncomment if using more than one and relying on firmware to position when changing).
 // The offset has to be X=0, Y=0 for the extruder 0 hotend (default extruder).
 // For the other hotends it is their distance from the extruder 0 hotend.
diff --git a/Marlin/example_configurations/Hephestos/Configuration.h b/Marlin/example_configurations/Hephestos/Configuration.h
index e25ea5bd8d..279c7ed20c 100644
--- a/Marlin/example_configurations/Hephestos/Configuration.h
+++ b/Marlin/example_configurations/Hephestos/Configuration.h
@@ -123,6 +123,9 @@
 // :[1,2,3,4]
 #define EXTRUDERS 1
 
+// For Cyclops or any "multi-extruder" that shares a single nozzle.
+//#define SINGLENOZZLE
+
 // Offset of the extruders (uncomment if using more than one and relying on firmware to position when changing).
 // The offset has to be X=0, Y=0 for the extruder 0 hotend (default extruder).
 // For the other hotends it is their distance from the extruder 0 hotend.
diff --git a/Marlin/example_configurations/Hephestos_2/Configuration.h b/Marlin/example_configurations/Hephestos_2/Configuration.h
index 5f2e0d5336..48d41042a3 100644
--- a/Marlin/example_configurations/Hephestos_2/Configuration.h
+++ b/Marlin/example_configurations/Hephestos_2/Configuration.h
@@ -120,6 +120,9 @@
 // :[1,2,3,4]
 #define EXTRUDERS 1
 
+// For Cyclops or any "multi-extruder" that shares a single nozzle.
+//#define SINGLENOZZLE
+
 // Offset of the extruders (uncomment if using more than one and relying on firmware to position when changing).
 // The offset has to be X=0, Y=0 for the extruder 0 hotend (default extruder).
 // For the other hotends it is their distance from the extruder 0 hotend.
diff --git a/Marlin/example_configurations/K8200/Configuration.h b/Marlin/example_configurations/K8200/Configuration.h
index 00fa13f355..8cbf115d7e 100644
--- a/Marlin/example_configurations/K8200/Configuration.h
+++ b/Marlin/example_configurations/K8200/Configuration.h
@@ -127,6 +127,9 @@
 // :[1,2,3,4]
 #define EXTRUDERS 1
 
+// For Cyclops or any "multi-extruder" that shares a single nozzle.
+//#define SINGLENOZZLE
+
 // Offset of the extruders (uncomment if using more than one and relying on firmware to position when changing).
 // The offset has to be X=0, Y=0 for the extruder 0 hotend (default extruder).
 // For the other hotends it is their distance from the extruder 0 hotend.
diff --git a/Marlin/example_configurations/RepRapWorld/Megatronics/Configuration.h b/Marlin/example_configurations/RepRapWorld/Megatronics/Configuration.h
index 6f1ee7d2e0..0a9ca7313c 100644
--- a/Marlin/example_configurations/RepRapWorld/Megatronics/Configuration.h
+++ b/Marlin/example_configurations/RepRapWorld/Megatronics/Configuration.h
@@ -120,6 +120,9 @@
 // :[1,2,3,4]
 #define EXTRUDERS 1
 
+// For Cyclops or any "multi-extruder" that shares a single nozzle.
+//#define SINGLENOZZLE
+
 // Offset of the extruders (uncomment if using more than one and relying on firmware to position when changing).
 // The offset has to be X=0, Y=0 for the extruder 0 hotend (default extruder).
 // For the other hotends it is their distance from the extruder 0 hotend.
diff --git a/Marlin/example_configurations/RigidBot/Configuration.h b/Marlin/example_configurations/RigidBot/Configuration.h
index 09166c2297..85a1332c88 100644
--- a/Marlin/example_configurations/RigidBot/Configuration.h
+++ b/Marlin/example_configurations/RigidBot/Configuration.h
@@ -120,6 +120,9 @@
 // :[1,2,3,4]
 #define EXTRUDERS 1  // Single extruder. Set to 2 for dual extruders
 
+// For Cyclops or any "multi-extruder" that shares a single nozzle.
+//#define SINGLENOZZLE
+
 // Offset of the extruders (uncomment if using more than one and relying on firmware to position when changing).
 // The offset has to be X=0, Y=0 for the extruder 0 hotend (default extruder).
 // For the other hotends it is their distance from the extruder 0 hotend.
diff --git a/Marlin/example_configurations/SCARA/Configuration.h b/Marlin/example_configurations/SCARA/Configuration.h
index b16745e513..e401ae888d 100644
--- a/Marlin/example_configurations/SCARA/Configuration.h
+++ b/Marlin/example_configurations/SCARA/Configuration.h
@@ -145,6 +145,9 @@
 // :[1,2,3,4]
 #define EXTRUDERS 1
 
+// For Cyclops or any "multi-extruder" that shares a single nozzle.
+//#define SINGLENOZZLE
+
 // Offset of the extruders (uncomment if using more than one and relying on firmware to position when changing).
 // The offset has to be X=0, Y=0 for the extruder 0 hotend (default extruder).
 // For the other hotends it is their distance from the extruder 0 hotend.
diff --git a/Marlin/example_configurations/TAZ4/Configuration.h b/Marlin/example_configurations/TAZ4/Configuration.h
index 6bc9693270..6cb82b6618 100644
--- a/Marlin/example_configurations/TAZ4/Configuration.h
+++ b/Marlin/example_configurations/TAZ4/Configuration.h
@@ -120,6 +120,9 @@
 // :[1,2,3,4]
 #define EXTRUDERS 1
 
+// For Cyclops or any "multi-extruder" that shares a single nozzle.
+//#define SINGLENOZZLE
+
 // Offset of the extruders (uncomment if using more than one and relying on firmware to position when changing).
 // The offset has to be X=0, Y=0 for the extruder 0 hotend (default extruder).
 // For the other hotends it is their distance from the extruder 0 hotend.
diff --git a/Marlin/example_configurations/WITBOX/Configuration.h b/Marlin/example_configurations/WITBOX/Configuration.h
index 1c87153c73..ae2cb6a21a 100644
--- a/Marlin/example_configurations/WITBOX/Configuration.h
+++ b/Marlin/example_configurations/WITBOX/Configuration.h
@@ -123,6 +123,9 @@
 // :[1,2,3,4]
 #define EXTRUDERS 1
 
+// For Cyclops or any "multi-extruder" that shares a single nozzle.
+//#define SINGLENOZZLE
+
 // Offset of the extruders (uncomment if using more than one and relying on firmware to position when changing).
 // The offset has to be X=0, Y=0 for the extruder 0 hotend (default extruder).
 // For the other hotends it is their distance from the extruder 0 hotend.
diff --git a/Marlin/example_configurations/adafruit/ST7565/Configuration.h b/Marlin/example_configurations/adafruit/ST7565/Configuration.h
index 96619e79c7..5d50a80614 100644
--- a/Marlin/example_configurations/adafruit/ST7565/Configuration.h
+++ b/Marlin/example_configurations/adafruit/ST7565/Configuration.h
@@ -120,6 +120,9 @@
 // :[1,2,3,4]
 #define EXTRUDERS 1
 
+// For Cyclops or any "multi-extruder" that shares a single nozzle.
+//#define SINGLENOZZLE
+
 // Offset of the extruders (uncomment if using more than one and relying on firmware to position when changing).
 // The offset has to be X=0, Y=0 for the extruder 0 hotend (default extruder).
 // For the other hotends it is their distance from the extruder 0 hotend.
diff --git a/Marlin/example_configurations/delta/biv2.5/Configuration.h b/Marlin/example_configurations/delta/biv2.5/Configuration.h
index f041c17ffd..aa47652189 100644
--- a/Marlin/example_configurations/delta/biv2.5/Configuration.h
+++ b/Marlin/example_configurations/delta/biv2.5/Configuration.h
@@ -120,6 +120,9 @@
 // :[1,2,3,4]
 #define EXTRUDERS 2
 
+// For Cyclops or any "multi-extruder" that shares a single nozzle.
+//#define SINGLENOZZLE
+
 // Offset of the extruders (uncomment if using more than one and relying on firmware to position when changing).
 // The offset has to be X=0, Y=0 for the extruder 0 hotend (default extruder).
 // For the other hotends it is their distance from the extruder 0 hotend.
diff --git a/Marlin/example_configurations/delta/generic/Configuration.h b/Marlin/example_configurations/delta/generic/Configuration.h
index c2dd7084f4..4300ccc53a 100644
--- a/Marlin/example_configurations/delta/generic/Configuration.h
+++ b/Marlin/example_configurations/delta/generic/Configuration.h
@@ -120,6 +120,9 @@
 // :[1,2,3,4]
 #define EXTRUDERS 1
 
+// For Cyclops or any "multi-extruder" that shares a single nozzle.
+//#define SINGLENOZZLE
+
 // Offset of the extruders (uncomment if using more than one and relying on firmware to position when changing).
 // The offset has to be X=0, Y=0 for the extruder 0 hotend (default extruder).
 // For the other hotends it is their distance from the extruder 0 hotend.
diff --git a/Marlin/example_configurations/delta/kossel_mini/Configuration.h b/Marlin/example_configurations/delta/kossel_mini/Configuration.h
index b12418733e..79a3ea82b0 100644
--- a/Marlin/example_configurations/delta/kossel_mini/Configuration.h
+++ b/Marlin/example_configurations/delta/kossel_mini/Configuration.h
@@ -120,6 +120,9 @@
 // :[1,2,3,4]
 #define EXTRUDERS 1
 
+// For Cyclops or any "multi-extruder" that shares a single nozzle.
+//#define SINGLENOZZLE
+
 // Offset of the extruders (uncomment if using more than one and relying on firmware to position when changing).
 // The offset has to be X=0, Y=0 for the extruder 0 hotend (default extruder).
 // For the other hotends it is their distance from the extruder 0 hotend.
diff --git a/Marlin/example_configurations/delta/kossel_pro/Configuration.h b/Marlin/example_configurations/delta/kossel_pro/Configuration.h
index 1608e36b7a..197aa574cc 100644
--- a/Marlin/example_configurations/delta/kossel_pro/Configuration.h
+++ b/Marlin/example_configurations/delta/kossel_pro/Configuration.h
@@ -126,6 +126,9 @@
 // :[1,2,3,4]
 #define EXTRUDERS 1
 
+// For Cyclops or any "multi-extruder" that shares a single nozzle.
+//#define SINGLENOZZLE
+
 // Offset of the extruders (uncomment if using more than one and relying on firmware to position when changing).
 // The offset has to be X=0, Y=0 for the extruder 0 hotend (default extruder).
 // For the other hotends it is their distance from the extruder 0 hotend.
diff --git a/Marlin/example_configurations/delta/kossel_xl/Configuration.h b/Marlin/example_configurations/delta/kossel_xl/Configuration.h
index 9ac5519151..1fb903aba6 100644
--- a/Marlin/example_configurations/delta/kossel_xl/Configuration.h
+++ b/Marlin/example_configurations/delta/kossel_xl/Configuration.h
@@ -113,6 +113,9 @@
 // :[1,2,3,4]
 #define EXTRUDERS 1
 
+// For Cyclops or any "multi-extruder" that shares a single nozzle.
+//#define SINGLENOZZLE
+
 // Offset of the extruders (uncomment if using more than one and relying on firmware to position when changing).
 // The offset has to be X=0, Y=0 for the extruder 0 hotend (default extruder).
 // For the other hotends it is their distance from the extruder 0 hotend.
diff --git a/Marlin/example_configurations/makibox/Configuration.h b/Marlin/example_configurations/makibox/Configuration.h
index 2fc005342b..67faff3fbd 100644
--- a/Marlin/example_configurations/makibox/Configuration.h
+++ b/Marlin/example_configurations/makibox/Configuration.h
@@ -120,6 +120,9 @@
 // :[1,2,3,4]
 #define EXTRUDERS 1
 
+// For Cyclops or any "multi-extruder" that shares a single nozzle.
+//#define SINGLENOZZLE
+
 // Offset of the extruders (uncomment if using more than one and relying on firmware to position when changing).
 // The offset has to be X=0, Y=0 for the extruder 0 hotend (default extruder).
 // For the other hotends it is their distance from the extruder 0 hotend.
diff --git a/Marlin/example_configurations/tvrrug/Round2/Configuration.h b/Marlin/example_configurations/tvrrug/Round2/Configuration.h
index 02c6e6c4df..5498e55403 100644
--- a/Marlin/example_configurations/tvrrug/Round2/Configuration.h
+++ b/Marlin/example_configurations/tvrrug/Round2/Configuration.h
@@ -120,6 +120,9 @@
 // :[1,2,3,4]
 #define EXTRUDERS 1
 
+// For Cyclops or any "multi-extruder" that shares a single nozzle.
+//#define SINGLENOZZLE
+
 // Offset of the extruders (uncomment if using more than one and relying on firmware to position when changing).
 // The offset has to be X=0, Y=0 for the extruder 0 hotend (default extruder).
 // For the other hotends it is their distance from the extruder 0 hotend.
diff --git a/Marlin/temperature.cpp b/Marlin/temperature.cpp
index ebebc3bd2c..10a5034727 100644
--- a/Marlin/temperature.cpp
+++ b/Marlin/temperature.cpp
@@ -417,19 +417,29 @@ float Temperature::get_pid_output(int e) {
 
         pid_output = pTerm[e] + iTerm[e] - dTerm[e];
 
+        #if ENABLED(SINGLENOZZLE)
+          #define _NOZZLE_TEST     true
+          #define _NOZZLE_EXTRUDER active_extruder
+          #define _CTERM_INDEX     0
+        #else
+          #define _NOZZLE_TEST     e == active_extruder
+          #define _NOZZLE_EXTRUDER e
+          #define _CTERM_INDEX     e
+        #endif
+
         #if ENABLED(PID_ADD_EXTRUSION_RATE)
-          cTerm[e] = 0;
-          if (e == active_extruder) {
+          cTerm[_CTERM_INDEX] = 0;
+          if (_NOZZLE_TEST) {
             long e_position = stepper.position(E_AXIS);
-            if (e_position > last_position[e]) {
-              lpq[lpq_ptr++] = e_position - last_position[e];
-              last_position[e] = e_position;
+            if (e_position > last_position[_NOZZLE_EXTRUDER]) {
+              lpq[lpq_ptr++] = e_position - last_position[_NOZZLE_EXTRUDER];
+              last_position[_NOZZLE_EXTRUDER] = e_position;
             }
             else {
               lpq[lpq_ptr++] = 0;
             }
             if (lpq_ptr >= lpq_len) lpq_ptr = 0;
-            cTerm[e] = (lpq[lpq_ptr] / planner.axis_steps_per_unit[E_AXIS]) * PID_PARAM(Kc, e);
+            cTerm[_CTERM_INDEX] = (lpq[lpq_ptr] / planner.axis_steps_per_unit[E_AXIS]) * PID_PARAM(Kc, e);
             pid_output += cTerm[e];
           }
         #endif //PID_ADD_EXTRUSION_RATE